Balabina N.M., Kalyagin A.N., Maksikova T.M. et al.

Effect of low-intensity laser radiation on hemostasis in patients with chronic obstructive pulmonary disease

Natalya M. Balabina1, Alexey N. Kalyagin, Tatyana M.Maksikova, Vadim A. Dulskiy, Valentina A. Haptanova, Olga V. Zhigalova, Larisa S. Andreeva

Abstract

Objective. The study presents results of the low-intensity intravenous (IV) laser radiation effect on some indicators of the hemostasis system and respiratory function of 83 patients with a chronic lung disease (COPD), stable phase, II-III (after GOLD scale), including 51 men and 32 women. The average COPD duration was 9.6±4.4 years. Materials and methods. All patients with COPD were randomly divided into 2 groups - comparison (30 people) and main (53 people). The control group consisted of 20 practically healthy people, matched by sex and age. Patients in the control group received only standard drug therapy with IGCC/DBA combination (budesonide/formoterol, salmeterol/fluticasone propionate inhalation at a therapeutic dose corresponding to the COPD clinical symptoms severity). Result and Discussion. In addition to the basic treatment, the main group received a course of intravenous lowintensity laser radiation. As established before the treatment initiation, patients with COPD experienced a decrease in FEV1 , Tiffno index, SaO2. Conclusion. The respiratory function disruption was accompanied by a significant activation of plasma hemostasis ( prothrombin time shortening, thrombin time, activated partial thromboplastin time) and a significant increase in platelet aggregation (increase in the aggregation degree, aggregation rate, decrease in the aggregation time). At the same time, in patients with COPD, a significant decrease in anticoagulant activity was observed before treatment, particularly antithrombin III decrease when compared with the control group (p <0.05) and CRP (main group: 0.86±0.02; control group: 0.85±0.02). The introduction of low-intensity laser radiation into the patients complex with COPD led to the these parameters normalization.

Keywords: COPD, plasma hemostasis, platelet aggregation, low-intensity intravenouslaser radiation